期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 25, 期 1, 页码 63-72出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2018.08.004
关键词
Hematopoietic stem cell transplantation; Myelodysplastic syndrome; GVHD-free; Relapse-free survival; Reduced-intensity conditioning; Antithymocyte globulin
资金
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Science, ICT and Future Planning [2015R1A2A2A04002756]
- National Research Foundation of Korea [2015R1A2A2A04002756] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Graft-versus-host disease-free, relapse-free survival (GRFS) is a composite endpoint that measures survival free of relapse or significant morbidity after allogeneic hematopoietic stem cell transplantation (HSCT). Consecutive adult patients (N = 324) who received HSCT with fludarabine and busulfan-based conditioning for myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia evolved from MDS were retrospectively analyzed. One-year and 3-year GRFS rates were 47.8% and 34.5%, respectively. Three fixed factors (circulating blast > 3%, high cytogenetic risk, and high comorbidity index) and 2 factors (which are) modifiable by clinicians (myeloablative conditioning [MAC] and low-dose [<7.5 mg/kg] antithymocyte globulin [ATG]) were independent factors for poor GRFS. Based on these 5 factors, 3 groups (3-year GRFS: 64.9% in low risk, 33.6% in intermediate risk, and 6.6% in high risk; P < .001) were identified. Fixed factor-adjusted GRFS in patients receiving reduced-intensity conditioning (RIC) plus high-dose ATG >= 7.5 mg/kg) was superior (P < .001) to those receiving MAC and/or low-dose ATG. Favorable influences of RIC plus ATG >= 7.5 mg/kg were evident in the low-risk group defined by fixed factors (3-year GRFS, 38.9% versus 4.4%; P < .001) but were not evident in the high-risk group (3-year GRFS, .0% versus 5.3%; P= .678). Conclusively, this study suggests that risk-adapted selection of conditioning intensity and ATG could improve qualified HSCT outcomes. (C) 2018 American Society for Blood and Marrow Transplantation.
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