期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 25, 期 1, 页码 151-156出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2018.08.005
关键词
Ultrasound; Compliance; Distensibility; Endothelial function; Cancer survivors
资金
- National Institutes of Health [R01 CA113930, R01CA112530]
- General Clinical Research Center Program [M01-RR00400]
- National Center for Research Resources [1UL1-RR033183]
- Clinical and Translational Science Institute at the University of Minnesota-Twin Cities [UUTR000114]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR000114]
This study examined the effects of hematopoietic cell transplantation (HCT) and associated preparative regimens on vascular structure and function. Measures of carotid artery stiffness and brachial artery endothelial-dependent dilation were obtained in patients who had survived >=( )2 years after HCT for hematologic malignancy and were diagnosed at <= 21 years. HCT survivors (n = 108) were examined: 66 received total body irradiation (TBI) alone or with a low-dose cranial radiation boost (TBI +/- LD-CRT), 19 received TBI plus high-dose cranial radiation (TBI+HD-CRT), and 23 received a chemotherapy-only preparative regimen (CHEMO). Siblings (n = 83) were invited to participate as control subjects. Although endothelial-dependent dilation did not differ between siblings and HCT survivors, carotid cross-sectional compliance, cross-sectional distensibility, diameter compliance, and diameter distensibility were greater in siblings than HCT survivors. Comparing the HCT preparative regimens, carotid cross-sectional compliance, cross-sectional distensibility, diameter compliance, diameter distensibility, and incremental elastic modulus were significantly lower in the TBI+HD-CRT group compared with siblings or with TBI +/- LD-CRT and CHEMO treatment groups. Cross-sectional distensibility and diameter compliance were significantly lower in the TBI+HD-CRT group compared with siblings. TBI +/- LD-CRT and CHEMO groups did not differ from each other in these vascular measures. HCT preparative regimens containing TBI+HD-CRT resulted in greater arterial decrements, indicating increased risk for cardiovascular disease. (C) 2018 American Society for Blood and Marrow Transplantation.
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