期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 20, 期 7, 页码 1040-1047出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2014.03.030
关键词
Acute leukemia; Acute lymphoblastic leukemia; Acute myelogenous leukemia; Allogeneic hematopoietic stem; cell transplantation; Extramedullary relapse
资金
- National Natural Science Foundation of China [81270645]
- Natural Science Foundation of Jiangsu Province [BK2012627]
- Natural Science Foundation of the Higher Education Institutions of Jiangsu Province [11KJB320015]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Jiangsu Provincial Health Office [H201125]
- Jiangsu Province Key Medical Center [ZX201102]
- Jiangsu Provincial Special Program of Medical Science [BL2012005]
- National Public Health Research Foundation [201202017]
Extramedullary relapse (EMR) of acute leukemia (AL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a contributor to post-transplantation mortality and remains poorly understood, especially the different characteristics of EMR in patients with acute myelogenous leukemia (AML) and those with acute lymphoblastic leukemia (ALL). To investigate the incidence, risk factors, and clinical outcomes of EMR for AML and ALL, we performed a retrospective analysis of 362 patients with AL who underwent allo-HSCT at the First affiliated Hospital of Soochow University between January 2001 and March 2012. Compared with patients with AML, those with ALL had a higher incidence of EMR (12.9% versus 4.6%; P = .009). The most common site of EMR was the central nervous system, especially in the ALL group. Multivariate analyses identified the leading risk factors for EMR in the patients with AML as advanced disease status at HSCT, hyperleukocytosis at diagnosis, history of extramedullary leukemia before HSCT, and a total body irradiation based conditioning regimen, and the top risk factors for EMR in the patients with ALL as hyperleukocytosis at diagnosis, adverse cytogenetics, and transfusion of peripheral blood stem cells. The prognosis for EMR of AL is poor, and treatment options are very limited; however, the estimated 3-year overall survival (OS) was significantly lower in patients with AML compared with those with ALL (0 versus 18.5%; P = .000). The characteristics of post-allo-HSCT EMR differed between the patients with AML and those with ALL possibly suggesting different pathogenetic mechanisms for EMR of AML and EMR of ALL after allo-HSCT; further investigation is needed. (C) 2014 American Society for Blood and Marrow Transplantation.
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