4.2 Article

Continuous Reduced Nonrelapse Mortality after Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Institution's Three Decade Experience

期刊

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 20, 期 8, 页码 1217-1223

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2014.04.021

关键词

Allogeneic stem cell transplantation; Nonrelapse mortality; Overall survival

资金

  1. Association pour la Recherche sur le Cancer (ARC) [3175]
  2. Fondation de France
  3. Fondation contre la Leucemie
  4. Agence de Biomedecine
  5. Association Cent pour Sang la Vie
  6. Association Laurette Fuguain
  7. International Research Group on Unrelated Hematopoietic Stem Cell Transplantation (IRGHET)
  8. Ligue contre le Cancer Grand-Ouest
  9. French National Cancer Institute (PHRC, INCa)
  10. Association for Training, Education and Research in Hematology, Immunology and Transplantation
  11. Region Pays de Loire

向作者/读者索取更多资源

This study analyzed changes in patients, transplantation, graft characteristics, and outcome among 827 patients who received their first allo-SCT in a single center between 1983 and 2010. In the 2001 to 2010 decade, compared with the 1983 to 1990 and 1991 to 2000 decades, patients were significantly older and presented with higher risk diseases, reduced intensity conditioning and alternative donors were used more often, and stem cell sources changed from bone marrow to peripheral blood stem cells and cord blood. In the 2001 to 2010 decade, we dbserved a significant decrease in nonrelapse mortality (NRM) (P = .0007 and P < .0001, respectively) and an increase in relapse incidence (P = .04 and P = .009, respectively), but overall survival (OS) was increased (P = .11 and P = .009, respectively), and there was a trend towards an increased progression-free survival (P = .30 and P = .09, respectively), as compared with the 1983 to 1990 and 1991 to 2000 decades. Chronic graft-versus-host disease (GVHD) was significantly increased, whereas grades III to IV acute GVHD remained stable. These data suggest that, despite the fact that older and higher risk patients with more comorbidities underwent transplantation in the last 10 years, NRM decreased while the incidence of relapse increased and the OS improved. (C) 2014 American Society for Blood and Marrow Transplantation.

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