期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 20, 期 8, 页码 1204-1210出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2014.04.017
关键词
BK virus; Hematopoietic stem cell transplantation; Hemorrhagic cystitis; Renal function
资金
- National Institutes of Health Immunobiology for Marrow Allografts for Leukemia [P01 CA023766]
Hematopoietic stem cell transplant (HSCT) recipients are at significant risk for BK virus (BKV) reactivation, hemorrhagic cystitis (HC), and renal dysfunction. We prospectively monitored 98 patients who had received HSCT by serial BKV PCR in the urine through day (D) +100 to analyze the relationship between BK viruria and HC, serum creatinine (Cr), and creatinine clearance (CrCl) through D +180 or death. Patients, median age 52 years (range, 20 to 73), received T cell depleted (50%) or cord blood allografts (21%). Median pre-HSCT BKV IgG titers were 1:10,240. Incremental increase in BKV IgG titers correlated with developing BK viruria >= 10(7) copies/mL. By D +100, 53 (54%) patients had BK viruria. BKV load in the urine increased at engraftment and persisted throughout D +100. HC developed in 10 patients (10%); 7 of 10 with BK viruria. In competing risk analyses, BK viruria >= 10(7) copies/mL, older age, cytomegalovirus reactivation, and foscarnet use were risk factors for HC. Cr and CrC at 2, 3, and 6 months after HSCT were similar between patients with and without BK viruria. (C) 2014 American Society for Blood and Marrow Transplantation.
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