期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 66, 期 2, 页码 307-312出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0091-3057(00)00182-9
关键词
dopamine; nucleus accumbens; d-amphetamine; raclopride; taste reactivity; ethanol consumption; rats
It was determined whether ethanol palatability in rats could be changed by manipulating the reinforcement experienced during limited access consumption. During the first 3 days of the experiment, initial taste reactivity (TR) testing to distilled water (1 day) and 10% alcohol (2 days) was performed. Following the establishment of baseline TR, separate groups of animals received bilateral microinjections (0.5 mu l/side) into the nucleus accumbens of either the nonspecific dopamine agonist d-amphetamine sulfate (20 mu g, n = 10), the D-2 antagonist raclopride (1.0 mu g, n = 8), or physiological saline (n = 5). The injections occurred at the same time each day for 5 consecutive days. Five minutes after the microinjection, the fluid-deprived rats were given 30-min access to 10% ethanol. Over the 3 days following drug administration, TR to distilled water and 10% alcohol was repeated. After this, the rats were once again given 30 min of access to 10% ethanol for 5 consecutive days, but without drug microinjection prior to alcohol access. A final TR exposure (the same as the others) was performed over the final 3 days of the study. Both raclopride and d-amphetamine administration produced reductions in ethanol consumption tin comparison to saline treatment). However, treatment with d-amphetamine and raclopride during ethanol consumption did not cause significant, conditioned changes in palatability as measured by the taste reactivity procedure. These results suggest that dopamine plays a role in the motivation to consume ethanol but this neurotransmitter is not involved in evaluating its incentive value. (C) 2000 Elsevier Science Inc.
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