期刊
NATURE BIOTECHNOLOGY
卷 18, 期 6, 页码 670-674出版社
NATURE PORTFOLIO
DOI: 10.1038/76531
关键词
genetic engineering; insect biology; stored grain; insect resistance; corn; host plant resistance; biotin; transgenic plants
Avidin is a glycoprotein found in chicken egg white, that sequesters the vitamin biotin. Here we show that when present in maize at levels of greater than or equal to 100 p.p.m., avidin is toxic to and prevents development of insects that damage grains during storage. Insect toxicity is caused by a biotin deficiency, as shown by prevention of toxicity with biotin supplementation. The avidin maize is not, however, toxic to mice when administered as the sole component of their diet for 21 days, These dates suggest that avidin expression in food or feed grain crops can be used as a biopesticide against a spectrum of stored-produce insect pests.
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