期刊
CHEMICAL RESEARCH IN TOXICOLOGY
卷 13, 期 6, 页码 462-470出版社
AMER CHEMICAL SOC
DOI: 10.1021/tx990209u
关键词
-
资金
- NCI NIH HHS [CA33572] Funding Source: Medline
- NICHD NIH HHS [HD36385] Funding Source: Medline
- NIGMS NIH HHS [GM41336] Funding Source: Medline
Emerging data strongly suggest that the oxidation of DNA bases can contribute to genomic instability. Structural changes to DNA, induced by base oxidation, may reduce the fidelity of DNA replication and interfere with sequence-specific DNA-protein interactions. We have examined the structures of a series of pyrimidine deoxynucleoside oxidation damage products in aqueous solution. The modified nucleosides studied include the deoxynucleoside derivatives of 5-hydroxyuracil, 5-hydroxycytosine, 5-(hydroxymethyl)uracil, 5-(hydroxymethyl)cytosine, 5-formyluracil, and 5-formylcytosine. The influence of base oxidation on ionization constants, sugar conformation, and tautomeric configuration has been determined on the basis of UV, proton, and nitrogen NMR spectra of the N-15-enriched derivatives. The potential biological. consequences of the structural perturbations resulting from base oxidation are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据