期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 18, 期 1, 页码 S56-S61出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2011.10.001
关键词
Bone marrow transplantation; Graft-versus-host disease; Cytokines
资金
- NCI NIH HHS [R01 CA166794] Funding Source: Medline
- NHLBI NIH HHS [R01 HL115761] Funding Source: Medline
- NIAID NIH HHS [R56 AI084219] Funding Source: Medline
The limitations of allogeneic transplantation are graft-versus-host disease (both acute and chronic), infection, and relapse. Acute GVHD has traditionally been thought of as a Th1-mediated disease with inflammatory cytokines (eg, inteferon [IFN]-gamma and tumor necrosis factor [TNF]) and cellular cytolysis mediating apoptotic target tissue damage in skin, gut, and liver. Chronic GVHD has not fit neatly into either Th1 or Th2 (eg, IL-4, IL-13) paradigms. Increasingly, the Th17 pathway of differentiation has been shown to play important roles in acute and chronic GVHD (aGVHD, cGVHD), particularly in relation to skin and lung disease. Here we discuss the IL-17 pathway of T cell differentiation and the accumulating evidence suggesting it represents an important new target for the control of deleterious alloimmune responses. Biol Blood Marrow Transplant 18: S56-S61 (2012) (C) 2012 American Society fir Blood and Marrow Transplantation
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