期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 30, 期 7, 页码 795-804出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0020-7519(00)00064-3
关键词
Microsporidia; opportunistic pathogens; animal hosts; genotypes; genome analysis; phylogeny
类别
Microsporidia are long-known parasites of a wide variety of invertebrate and vertebrate hosts. The emergence of these obligate intracellular organisms as important opportunistic pathogens during the AIDS pandemic and the discovery of new species in humans renewed interest in this unique group of organisms. This review summarises recent advances in the field of molecular biology of microsporidia which (i) contributed to the understanding of the natural origin of human-infecting microsporidia, (ii) revealed unique genetic features of their dramatically reduced genome and (iii) resulted in the correction of their phylogenetic placement among eukaryotes from primitive protozoans to highly evolved organisms related to fungi. Microsporidia might serve as new intracellular model organisms in the future given that gene transfer systems will be developed. (C) 2000 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
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