期刊
AMERICAN JOURNAL OF PSYCHIATRY
卷 157, 期 6, 页码 1004-1006出版社
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.157.6.1004
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Objective: The authors' goal was to assess the efficacy of sertraline in the treatment of binge eating disorder. Method: Thirty-four outpatients with DSM-IV binge eating disorder were randomly assigned to receive either sertraline (N=18) or placebo (N=16) in a 6-week, double-blind, flexible-dose (50-200 mg) study. Except for response level, outcome measures were analyzed by random regression methods, with treatment-by-time interaction as the effect measure. Results: Compared with placebo, sertraline was associated with a significantly greater rate or reduction in the frequency of binges, clinical global severity, and body mass index as well as a significantly greater rate of increase in clinical global improvement. Patients receiving sertraline who completed the study demonstrated a higher level of response, although the effect was not significant. Conclusions: In a 6-week trial, sertraline was effective and well tolerated in the treatment of binge eating disorder.
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