期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 18, 期 3, 页码 458-465出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2011.07.025
关键词
Hemorrhagic cystitis; Adenovirus; BK virus; Stem cell transplantation; Immune reaction
资金
- Ministry of Education, Culture, Sports, Science, and Technology in Japan [23390254]
- Grants-in-Aid for Scientific Research [22591063, 23390254, 23659490, 21390295] Funding Source: KAKEN
Virus-associated hemorrhagic cystitis (HC) is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (HSCT). Although numerous studies have attempted to identify factors that predispose patients to viral HC, its causes remain controversial. We analyzed retrospectively the results of 266 allogeneic HSCTs to identify factors associated with HC. Of this group, 42 patients (15.8%) were diagnosed with viral HC, because of either adenovirus (ADV; n = 26; 9.8%) or BK virus (BKV; n = 16; 6.0%). ADV-HC was frequently associated with T cell purging, and was less common in patients with acute graft-versus-host-disease (GVHD). Conversely, BKV-HC was more frequently observed in patients with excessive immune reactions such as GVHD, preengraftment immune reaction, and hemophagocytic syndrome. These observations indicate that ADV- and BKV-HC may differ significantly in their risk factors and pathogenesis. Profound immune deficiency is more likely to be associated with ADV-HC, whereas immune hyperactivity might play a key role in BKV-HC. Biol Blood Marrow Transplant 18: 458-465 (2012) (C) 2012 American Society for Blood and Marrow Transplantation
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