期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 17, 期 11, 页码 1704-1708出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2011.04.013
关键词
Graft rejection; Engraftment; Unit predominance
资金
- National Cancer Institute [CA65493, CA77598]
- Children's Cancer Research Fund
- American Society of Blood and Marrow Transplantation
- Leukemia and Lymphoma Society
Recent registry data suggest that host-versus-graft alloreactions mediated by anti-donor HLA antibodies in recipients of adult allogeneic hematopoietic stem cells or single-unit umbilical cord blood (UCB) contribute to the risk of graft failure. The present study evaluated the impact of anti-HLA antibodies on engraftment and unit predominance in 126 double-UCB (dUCB) recipients. Eighteen dUCB recipients were identified with at least 1 of 2 UCB units recognized by anti-HLA antibodies directed against donor-directed HLA-specific antibodies (DSAs). Overall, 9 of 12 patients who had DSAs against 1 of the 2 UCB units composing the graft and 5 of 6 patients who had DSAs against both units engrafted. The cumulative incidence of engraftment was similar in patients with and without DSAs (83% vs 78%). Thus, our data do not support a negative effect of anti-HLA antibodies on engraftment, at least in the setting of cyclosporine and mycophenolate mofetil and the conditioning regimens used at the University of Minnesota, and argue against routine screening for use in graft selection before dUCB transplantation. Further studies are needed to fully understand the value of anti-HLA antibody testing in dUCB graft selection and its impact on transplantation outcomes. Biol Blood Marrow Transplant 17: 1704-1708 (2011) (C) 2011 American Society for Blood and Marrow Transplantation
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据