期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 17, 期 11, 页码 1708-1713出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2011.05.006
关键词
Varicella; Allogeneic; Immunization
资金
- National Shingles Foundation
- [CA23766]
There are limited studies assessing the live attenuated varicella vaccine following allogeneic hematopoietic cell transplantation (alloHCT). Because of the morbidity of varicella acquired after childhood, we immunized and retrospectively analyzed the safety and immunogenicity of this vaccine in 46 varicella zoster virus (VZV) seronegative patients <20 years old at HCT who achieved a CD4 cell count >= 200/mu L, were off immunosuppression, and responded to >= 1 post-HCT vaccines. Two vaccinated patients lacking follow-up titers were excluded from analysis. Stem cells were derived from an HLA-matched sibling (n = 18) or an alternative (HLA mismatched related or unrelated) donor (n = 26). Median time to vaccination was 4 years. Sixty-four percent of patients seroconverted following I immunization. There was no significant difference in response between recipients of a matched related or alternative donor graft (P = .2) or between those given a T cell-depleted or T-replete alternative donor graft (P = .27). Three of 44 patients developed a self-limited varicella-like rash within 2.5 weeks of immunization. With a median follow-up of 29.1 (range: 6.9-167.1) months, there were no subsequent cases of varicella-like rashes. No patient developed shingles. This study suggests that this vaccine is safe and immunogenic when given according to preset clinical and immunologic milestones, warranting larger prospective studies in patients >= 24 months following HCT as outlined in current post-HCT vaccine guidelines. Biol Blood Marrow Transplant 17: 1708-1713 (2011) (C) 2011 American Society for Blood and Marrow Transplantation
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据