期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 17, 期 3, 页码 341-350出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2010.05.007
关键词
Treosulfan; Acute leukemia; Myelodysplastic syndrome; Bone marrow transplantation; Reduced intensity
资金
- Medac GmbH
- National Cancer Institute
- National Heart Lung Blood Institute [CA100394, HL036444, HL088021]
In this prospective study 60 patients of median age 46 (range: 5-60 years), with acute myelogenous leukemia (AML; n = 44), acute lymphoblastic leukemia (ALL; n = 3), or myelodysplastic syndrome (MDS; n = 13) were conditioned for allogeneic hematopoietic cell transplantation with a treosulfan/fludarabine (Flu) combination. Most patients were considered at high risk for relapse or nonrelapse mortality (NRM). Patients received intravenous treosulfan, 12 g/m(2)/day (n = 5) or 14 g/m(2)/day (n = 55) on days 6 to 4, and Flu (30 mg/m(2)/day) on days 6 to 2, followed by infusion of marrow (n = 7) or peripheral blood stem cells (n = 53) from HLA-identical siblings (n = 30) or unrelated donors (n = 30). All patients engrafted. NRM was 5% at day 100, and 8% at 2 years. With a median follow-up of 22 months, the 2-year relapse-free survival (RFS) for all patients was 58% and 88% for patients without high-risk cytogenetics. The 2-year cumulative incidence of relapse was 33% (15% for patients with MDS, 34% for AML in first remission, 50% for AML or ALL beyond first remission and 63% for AML in refractory relapse). Thus, a treosulfan/Flu regimen was well tolerated and yielded encouraging survival and disease control with minimal NRM. Further trials are warranted to compare treosulfan/Flu to other widely used regimens, and to study the impact of using this regimen in more narrowly defined groups of patients. Biol Blood Marrow Transplant 17: 341-350 (2011) (C) 2011 American Society for Blood and Marrow Transplantation
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