期刊
FARMACO
卷 55, 期 6-7, 页码 439-447出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/S0014-827X(00)00063-X
关键词
N-[4-(propyl)cyclohexyl]-amides; anti-inflammatory agents; analgesic agents
Seventeen (un)substituted N-[4-(propyl)cyclohexyl]-amides (6a-h, 7a-h and 8) were synthesized and rested as anti-inflammatory and analgesic agents. The substituents on the aromatic ring were chosen in order to study the influence of electron-withdrawing or electron-donating residues, that change the electronic density on the aromatic moiety. The pharmacological results allow drawing some preliminary considerations on structure-activity relationships. (C) 2000 Elsevier Science S.A. All rights reserved.
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