期刊
GLYCOCONJUGATE JOURNAL
卷 17, 期 7-9, 页码 617-626出版社
SPRINGER
DOI: 10.1023/A:1011034912226
关键词
alpha 1,3fucose; alpha 1,6fucose; sialic acid; poly alpha 2,8sialic acid; surface membrane glycoforms; cystic fibrosis; lactosylated polylysine gene therapy vector
Terminal glycosylation has been a recurring theme of the laboratory. In cystic fibrosis (CF), decreased sialic acid and increased fucosyl residues in alpha1,3 position to antennary N-acetyl glucosamine is the CF glycosylation phenotype. The glycosylation phenotype is reversed by transfection of CF airway cells with wtCFTR. In neuronal cells, polymers of alpha2,8sialyl residues are prominent in oligodendrocytes and human neuroblastoma. These findings are discussed in relationship to early studies in our laboratories and those of other investigators. The potential extension of these concepts to future clinical therapeutics is presented.
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