期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 105, 期 12, 页码 1731-1740出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI8472
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资金
- NHLBI NIH HHS [HL57505, HL-56989, P50 HL056989, R01 HL057505] Funding Source: Medline
- NIAID NIH HHS [R01 AI-40305, R01 AI040305] Funding Source: Medline
The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, me isolated a panel of oxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC). These Abs block uptake of OxLDL by macrophages, recognize similar oxidation-specific epitopes on apoptotic cells, and are deposited in atherosclerotic lesions. The Abs were found to be structurally and functionally identical to classic natural T15 anti-PC Abs that are of B-1 cell origin and are reported to provide optimal protection from virulent pneumococcal infection. These findings suggest that there has been natural selection for B-1 cells secreting oxidation-specific/T15 antibodies, both for their role in natural immune defense and for housekeeping roles against oxidation-dependent neodeterminants in health and disease.
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