期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 278, 期 6, 页码 G967-G973出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.2000.278.6.G967
关键词
palmitate; glycerol; reesterification; insulin; humans
资金
- NCRR NIH HHS [M01-RR-00334] Funding Source: Medline
- NIDDK NIH HHS [DK-19525, DK-40566] Funding Source: Medline
On the basis of the finding that plasma glycerol concentration is not controlled by clearance in healthy humans, it has been proposed that elevated plasma free fatty acid (FFA) and glycerol concentrations in cirrhotic subjects are caused by accelerated lipolysis. This proposal has not been validated. We infused 10 volunteers, 10 cirrhotic subjects, and 10 patients after orthotopic liver transplantation (OLT) with [1-C-13]palmitate and [H-2(5)]glycerol to compare fluxes (R-a) and FFA oxidation. Cirrhotic subjects had higher plasma palmitate (52%) and glycerol (33%) concentrations than controls. Palmitate R-a was faster (1.45 +/- 0.18 vs. 0.85 +/- 0.17 mu mol . kg(-1) . min(-1)) but glycerol R-a and clearance slower (1.20 +/- 0.09 vs. 1.90 +/- 0.24 mu mol . kg(-1) . min(-1) and 21.2 +/- 1.2 vs. 44.7 +/- 4.9 ml . kg(-) . h(-1), respectively) than in controls. After OLT, plasma palmitate and glycerol concentrations and palmitate R-a did not differ, but glycerol R-a (1.16 +/- 0.11 mu mol . kg(-1) . min(-1)) and clearance (26.7 +/- 2.4 ml . kg(-) . h(-1)) were slower than in controls. We conclude that 1) impaired reesterification, not accelerated lipolysis, elevates FFA in cirrhotic subjects; 2) normalized FFA after OLT masks impaired reesterification; and 3) plasma glycerol concentration poorly reflects lipolytic rate in cirrhosis and after OLT.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据