期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 16, 期 3, 页码 311-319出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2009.12.002
关键词
CCR5; GVHD; Chemokine; CD4; CD8
资金
- Wendy Will Case Cancer Fund
- National Institutes of Health [CA18029, CA15704, CA78902]
Allogeneic bone marrow transplantation (BMT) is an effective therapy for hematologic malignancies. However graft-versus-host disease (GVHD) is a major limiting factor for a successful patient outcome. GVHD is a result of alloimmune responses of donor T lymphocytes attacking the recipient's cells and tissues. Chemokine receptor CCR5 plays a role in solid organ allograft rejection and mediates murine GVHD pathogenesis. Herein, we report that infiltrating lymphocytes in the skin of human acute GVHD (aGVHD) samples are predominantly CCR5(+) T cells. In addition, we characterized the features of the CCR5 expression on alloreactive T lymphocytes. We found that the CCR5(+) population exhibits the characteristics of the activated effector T cell phenotype. CCR5 expression is upregulated upon allogenic stimulation, and CCR5(+) cells are proliferating with coexpression of T cell activation markers. Furthermore, the activated T cells producing inflammatory cytokine tumor necrosis factor (TNF)alpha, interleukin (IL)-2, or interferon (IFN)-gamma, are positive for CCR5. Thus, CCR5 is a marker for GVHD effector cells and CCR5(+) T cells are active participants in the pathogenesis of human aGVHD. Biol Blood Marrow Transplant 16: 311-319 (2010) (C) 2010 American Society for Blood and Marrow Transplantation
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