期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 44, 期 6, 页码 1697-1700出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.44.6.1697-1700.2000
关键词
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To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythromycin enhanced sensitivity with increased intracellular vincristine accumulation and inhibited the calcein-AM efflux. Our findings suggest that the two agents are possible MRP substrates and may competitively inhibit MRP function as a drug efflux pump.
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