期刊
NEUROSCIENCE RESEARCH
卷 37, 期 2, 页码 113-125出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0168-0102(00)00107-3
关键词
cerebral ischemia; necrosis; apoptosis; hippocampus; electron microscopy
资金
- NINDS NIH HHS [NS 33103, NS 38053] Funding Source: Medline
Morphological changes of CA1 and CA3 pyramidal neurons in rat hippocampus at different intervals following transient forebrain ischemia were examined to determine the nature of post-ischemic cell death in these regions. In the CAI region, swelling of small dendrites occurred at similar to 24 h reperfusion. At similar to 48 h reperfusion, swelling was found in large dendrites of many CA1 neurons and the mitochondria and endoplasmic reticulum (ER) were dilated. A small portion of neurons showed chromatin aggregation and nuclear indentation without swelling signs. At similar to 60 h reperfusion, swelling of somata was evident in many neurons. Large dense chromatin clumps with round or ovoid contour were found in other neurons. At 72 and 96 h after ischemia, many large vacuoles and glias with active phagocytosis were observed. At 7 days after ischemia, the tissue was compact and many glias were found in the region. Most of the CA3 neurons had normal appearance after ischemia. A total of 5-10% CA3 neurons exhibited shrinking nuclei and chromatin aggregation at similar to 24 h reperfusion. The number of these neurons decreased overtime and disappeared at 72 h after ischemia. These results demonstrate the co-existence of necrosis and apoptosis in the CA1 region after transient forebrain ischemia. Most CA3 neurons remained intact after ischemia while a small portion of them showed apoptotic cell death. (C) 2000 Elsevier Science Ireland Ltd and the Japanese Neuroscience Society. All rights reserved.
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