期刊
NERVENARZT
卷 71, 期 6, 页码 459-469出版社
SPRINGER
DOI: 10.1007/s001150050607
关键词
Parkinson's disease; motor system; limbic system; lewy bodies; lewy neurites; cytoskeleton; alpha-synuclein
Morbus Parkinson is a progressive degenerative disease of the human centra I, peripheral, and enteric nervous systems. In the course of the disease, not only the substantia nigra, but also extranigral components of the motor system, as well as numerous limbic system and autonomic centers undergo serious damage. Accordingly, Parkinson's disease is a multisystem disorder. Only specific types of projection neurons fall victim to it. The first manifestation of the pathological process which causes the disease are abnormalities of the neuronal cytoskeleton. Intracytoplasmic inclusions evolving in the form of Lewy bodies in perikarya and Lewy neurites in the neuronal processes result in premature cell death of the affected neurons. On the basis of this selective neuronal vulnerability, a categorization emerges of the pathological changes within the nervous system and corresponding functional impairments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据