期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 10, 期 11, 页码 1303-1306出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00208-0
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资金
- NCI NIH HHS [P01CA68425, CA-08748, CA-28824] Funding Source: Medline
Geldanamycin (GDM) binds to the Hsp90 chaperone protein resulting in the degradation of several important signaling proteins. A series of GDM-testosterone linked hybrids has been synthesized and evaluated for activity against prostate cancer cell lines. The hybrid with the greatest activity exhibits potent and selective cytotoxicity against prostate cancer cells containing the androgen receptor. (C) 2000 Elsevier Science Ltd. All rights reserved.
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