期刊
LIFE SCIENCES
卷 67, 期 3, 页码 291-300出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0024-3205(00)00622-6
关键词
acute-phase response; cytokines; interleukin-6; tumour necrosis factor alpha; type 2 diabetes
Type 2 diabetes is associated with increased circulating concentrations of markers of the acute-phase response and interleukin-6 (IL-6). An augmented acute-phase response may be a mechanism which explains many of the clinical and biochemical features of type 2 diabetes and its complications. We sought to confirm that circulating concentrations of the cytokine acute-phase mediators IL-6 and tumour necrosis factor alpha [TNF alpha] are elevated in type 2 diabetes, and investigated blood as a source of cytokines in type 2 diabetes. Blood samples from 20 type 2 diabetic and 17 age-matched healthy subjects were incubated in vitro for 24 hr with and without lipopolysaccharide (LPS) stimulation and secreted cytokines measured. Plasma IL-6 and TNF alpha were significantly increased in type 2 diabetes compared to normal subjects. However, basal production of IL-6 and TNF alpha in cultured diabetic blood was markedly depressed in comparison with non-diabetic samples. IL-6 and TNF alpha production was increased in blood in response to LPS, reaching similar levels in diabetic and non-diabetic subjects, though IL-6 was slightly but significantly higher in controls. We conclude that circulating levels of IL-6 and TNF alpha are increased in type 2 diabetes but there is downregulation of basal cytokine production in blood cells in type 2 diabetes, Blood has the capacity to produce cytokines in diabetes which contribute to the augmented acute-phase response, but the main source of the increased plasma IL-6 and TNF alpha concentrations may be from non-circulating cells. (C) 2000 Elsevier Science Inc. All rights reserved.
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