期刊
SCIENCE
卷 288, 期 5472, 页码 1789-1796出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.288.5472.1789
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资金
- NIAID NIH HHS [R01 AI 44596, N01 AI 85338] Funding Source: Medline
- NICHD NIH HHS [R01-HD37356] Funding Source: Medline
HIV-1 sequences were analyzed to estimate the timing of the ancestral sequence of the main group of HIV-1, the strains responsible for the AIDS pandemic. Using parallel supercomputers and assuming a constant rate of evolution, we applied maximum-likelihood phylogenetic methods to unprecedented amounts of data for this calculation. We validated our approach by correctly estimating the timing of two historically documented points. Using a comprehensive full-length envelope sequence alignment, we estimated the date of the Last common ancestor of the main group of HIV-1 to be 1931 (1915-41). Analysis of a gag gene alignment, subregions of envelope including additional sequences, and a method that relaxed the assumption of a strict molecular clock also supported these results.
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