期刊
CELLULAR IMMUNOLOGY
卷 202, 期 2, 页码 136-139出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/cimm.2000.1654
关键词
Helicobacter pylori; CagA; T cell proliferation
The pathogenicity of chronic gastroduodenal diseases is very often related to Helicobacter pylori infections. Most H. pylori strains carry the cagA gene encoding an immunodominant 120- to 128-kDa protein which is considered a virulence marker. The majority of CagA-positive H. pylori isolates also produce a 95-kDa protein cytotoxin (VacA) causing vacuolation and degradation of mammalian cells. In our previous study we have shown that live H. pylori bacteria and their sonicates inhibit PHA-driven proliferation of human T lymphocytes. The H. pylori CagA and VacA proteins were suspected of a paralyzing effect of H. pylori on T cell proliferation. In this report, by using isogenic H. pylori mutant strains defective in CagA and VacA proteins, we determined that CagA is responsible for the inhibition of PHA-induced proliferation of T cells. (C) 2000 Academic Press.
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