期刊
SCIENCE
卷 288, 期 5474, 页码 2205-2208出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.288.5474.2205
关键词
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in Caenorhabditis elegans, the gonad acquires two U-shaped arms by the directed migration of its distal tip cells (DTCs) along the body wall basement membranes. Correct migration of DTCs requires the mig-17 gene, which encodes a member of the metalloprotease-disintegrin protein family. The MIG-17 protein is secreted from muscle cells of the body wall and Localizes in the basement membranes of gonad, This localization is dependent on the disintegrin-like domain of MIG-17 and its catalytic activity, These results suggest that the MIG-17 metalloprotease directs migration of DTCs by remodeling the basement membrane.
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