期刊
BIOLOGY LETTERS
卷 5, 期 3, 页码 413-416出版社
ROYAL SOC
DOI: 10.1098/rsbl.2008.0662
关键词
ageing; mutation; substitution; soma; antagonistic pleiotropy; reactive oxygen species
资金
- Agence Nationale de la Recherche [06-BIOS-0001-01]
The evolutionary rate of mitochondrial DNA (mtDNA) is highly variable across lineages in animals, and particularly in mammals. This variation has been interpreted as reflecting variations in metabolic rate: mitochondrial respiratory activity would tend to generate mutagenic agents, thus increasing the mutation rate. Here we review recent evidence suggesting that a direct, mechanical effect of species metabolic rate on mtDNA evolutionary rate is unlikely. We suggest that natural selection could act to reduce the (somatic) mtDNA mutation rate in long-lived species, in agreement with the mitochondrial theory of ageing.
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