期刊
NEUROSCIENCE LETTERS
卷 287, 期 2, 页码 85-88出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)01138-1
关键词
denervation; motor cortex; recovery of function; behavioral compensation; collosotomy; dendritic arborization; structural plasticity; layer V pyramidal neurons
资金
- NIMH NIH HHS [MH52361, MH56361] Funding Source: Medline
This study tests the hypothesis that degeneration of a neocortical pathway may facilitate behavioral ly-induced growth of neurons in a connected region of the cortex. Degeneration of trancallosal afferents to the motor cortex and changes in forelimb use were independently manipulated in adult rats. The combination of degeneration and behavioral change resulted in the growth of layer V pyramidal neuron dendrites which was not found as a result of either denervation or behavioral manipulation alone. These results indicate that mild degeneration in the adult brain can facilitate neuronal growth when accompanied by appropriate behavioral demand, a finding which has implications for rehabilitative therapy after brain damage. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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