期刊
ONCOGENE
卷 19, 期 28, 页码 3216-3219出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1203667
关键词
Erk2; Ras; signal transduction; extracellular matrix; cell adhesion
资金
- NCI NIH HHS [R29 CA74230] Funding Source: Medline
- NHLBI NIH HHS [P01 HL57900] Funding Source: Medline
- NIGMS NIH HHS [F32 GM18298] Funding Source: Medline
Previous work showed that integrin stimulation triggers activation of the c-Abl tyrosine kinase and its transient localization to focal adhesions. We now report that plating cells on fibronectin triggers association of Grb2 with c-Abl, suggesting possible involvement of c-Abl with integrin activation of the MAP kinase pathway. Expression of a kinase-defective c-Abl specifically inhibited the transient induction of Erk2 activity following cell adhesion, Together with the known ability of activated, oncogenic forms of c-Abl to activate Ras and the MAP kinase pathway, these data suggest that c-myc contributes to the integrin induction of MAP kinase activity.
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