期刊
BIOLOGY DIRECT
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1745-6150-9-22
关键词
DNA polymerase; Exaptation; Poxviruses; Evolution of viruses
类别
资金
- intramural funds of the US Department of Health and Human Services
- Independent Research/Development program at the National Science Foundation
Through the course of their evolution, viruses with large genomes have acquired numerous host genes, most of which perform function in virus reproduction in a manner that is related to their original activities in the cells, but some are exapted for new roles. Here we report the unexpected finding that protein F12, which is conserved among the chordopoxviruses and is implicated in the morphogenesis of enveloped intracellular virions, is a derived DNA polymerase, possibly of bacteriophage origin, in which the polymerase domain and probably the exonuclease domain have been inactivated. Thus, F12 appears to present a rare example of a drastic, exaptive functional change in virus evolution. Reviewers: This article was reviewed by Frank Eisenhaber and Juergen Brosius. For complete reviews, go the Reviewers' Reports section.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据