期刊
FEBS LETTERS
卷 476, 期 1-2, 页码 52-54出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01669-0
关键词
signal transduction; redox; peroxide; rac1; NADPH oxidase
资金
- NCI NIH HHS [CA61774] Funding Source: Medline
- NIGMS NIH HHS [GM43880] Funding Source: Medline
Reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide appear to be transiently produced in response to growth factor and cytokine stimulation. A variety of evidence suggests that this ligand-stimulated change in the cellular redox state participates in downstream signal transduction. This review will focus on the effects of ROS on signal transduction pathways, the molecules that regulate intracellular ROS production and the potential protein targets of oxidants. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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