期刊
FEBS LETTERS
卷 476, 期 1-2, 页码 62-67出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01672-0
关键词
nuclear receptor; ligand binding domain; transcriptional regulation; ligand-protein interaction; selectivity; molecular recognition
Nuclear hormone receptors are transcription factors regulated by lipophilic ligands, These hormones bind to their nuclear receptor targets using an induced fit mechanism that triggers a large conformational change and generates the proper surface for the binding of protein coactivators. The molecular details of the various steps of this activation process or its inhibition by antagonists are now understood for several nuclear receptors, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V, All rights reserved.
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