期刊
NEUROSCIENCE LETTERS
卷 287, 期 3, 页码 199-202出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)01161-7
关键词
ammonia; kindling; piriform cortex; seizure threshold; temporal lobe epilepsy; toluene
Seizures in human temporal lobe epilepsy are characterized by paroxysmal activity in the limbic system. The primary olfactory or piriform cortex is a central part of the limbic system. Since a relationship between olfactory sensation and limbic seizures has been described, we were interested in the effect of strong olfactory stimulation on the seizure susceptibility of amygdala-kindled rats, a model of human temporal lobe epilepsy. Olfactory stimulation with toluene was able to suppress seizures in most kindled rats after stimulation at 20% above the threshold for eliciting epileptic afterdischarges. Olfactory stimulation with toluene or ammonia increased the threshold by 27 and 25% compared to control conditions, Our data substantiate that olfactory brain regions, such as the piriform cortex, are involved in amygdala-kindled seizures and suggest that strong physiological stimulation of this nucleus interferes with on-going seizure activity in the limbic system. Thus, olfactory stimulation could contribute to anticonvulsant therapy. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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