Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10-deficient mice

Interleukin-10 (IL-10) inhibits tumor necrosis factor (TNF) production. We investigated the role of endogenous IL-IO in brain TNF production. We injected IL-10-knockout mice with lipopolysaccharide (LPS,2.5 mu g/mouse i.c.v.). Brain TNF and IL-6 levels were more elevated and persisted longer in IL-10-deficient mice compared with wild type mice, suggesting that IL-10 is an important negative feedback inhibitor of TNF and IL-6 production in the CNS. (C) 2000 Elsevier Science BN. All rights reserved.