期刊
FEBS LETTERS
卷 476, 期 1-2, 页码 3-7出版社
WILEY
DOI: 10.1016/S0014-5793(00)01659-8
关键词
vertebrate genome; Fugu; gene structure; phylogenetic relationship
At 400 Mb, the Japanese pufferfish, Fugu rubripes, has the smallest vertebrate genome but has a similar gene repertoire to other vertebrates. Its genes are densely packed with short intergenic and intronic sequences devoid of repetitive elements. It likely has a mutational bias towards DNA elimination and is probably close to a 'minimal' vertebrate genome. As such it is a useful reference genome for gene discovery and gene validation in other vertebrates. Its usefulness in the discovery of conserved regulatory elements has already been demonstrated. The Fugu genome sequence is a good complement to genetic studies in other vertebrates. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B,V. All rights reserved.
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