期刊
BIOLOGY OF THE CELL
卷 92, 期 3-4, 页码 215-233出版社
WILEY
DOI: 10.1016/S0248-4900(00)01065-0
关键词
calcium; fertilization; egg; tyrosine kinase; phospholipase C
类别
Interaction of sperm and egg at fertilization induces well-coordinated molecular events including specific recognition between species, adhesion and fusion, that lead to the formation of a zygote, a totipotent cell that develops into a new individual. A calcium signal, common to a great number of species, from marine invertebrates to mammals, is essential to activate the metabolism of the unfertilized oocyte. However, how fertilization triggers this calcium signal and initiates development of the early embryo is far from understood. The signaling pathways activated in eggs may be similar to those described in somatic cells, since changes in intracellular free calcium and in mitosis activating protein (MAP) kinase activity occur in both systems after activation. Several hypotheses are currently proposed, implying a spermatic ligand binding to a specific receptor expressed at the egg surface, or where the fused sperm either allows the transit of external calcium into the egg or injects one (or several) activating factor(s). It is still not known which of these ideas is true. We concentrate in this review on the possible signaling pathways involving IF, (inositol trisphosphate), since its production is involved in most species to generate the fertilization calcium wave. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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