期刊
IMMUNITY
卷 13, 期 1, 页码 95-105出版社
CELL PRESS
DOI: 10.1016/S1074-7613(00)00011-X
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资金
- Wellcome Trust [087618] Funding Source: Medline
While CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7. We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and lFN gamma from recently activated T cells and contributes to T cell-dependent B help in vivo. Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell-dependent immune responses.
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