期刊
NATURE IMMUNOLOGY
卷 1, 期 1, 页码 23-29出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/76877
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资金
- NIGMS NIH HHS [R01 GM038542, R01 GM038542-12] Funding Source: Medline
The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell biology and immunology studies to explain the role of the actin cytoskeleton in creating the molecular basis for immunological synapse formation and T cell signaling.
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