期刊
INFECTION AND IMMUNITY
卷 68, 期 7, 页码 4349-4353出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.7.4349-4353.2000
关键词
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Systemic and mucosal antibody responses against both the major subunit of colonization factor antigen I (CFA/I) of enterotoxigenic Escherichia coli (ETEC) and the somatic lipopolysaccharide expressed by recombinant bivalent Salmonella vaccine strains were significantly enhanced by coadministration of a detoxified derivative with preserved adjuvant effects of the ETEC heat-labile toxin, LT(R192G). The results further support the adjuvant effects of LT(R192G) and represent a simple alternative to improve responses against passenger antigens expressed by orally delivered Salmonella vaccine strains.
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