期刊
VACCINE
卷 18, 期 26, 页码 3011-3017出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(00)00109-2
关键词
Th1/Th2 responses; Parasite Surface Antigen 2 vaccine; therapeutic DNA vaccine; interferon gamma
Prophylactic DNA vaccination protects mice against infection with Leishmania major by inducing an exclusive Th1 immune response dominated by the production of IFN-gamma. Here we show that DNA vaccines, initially designed to prevent infection, can also have a significant therapeutic effect. In L. major infected mice, vaccination with DNA encoding the Parasite Surface Antigen/gp46/M2 causes reduction in lesion size and promotes healing in both genetically resistant C3H/He mice and susceptible BALB/c mice. The therapeutic effect is underpinned by a shift in the T cell-derived cytokine environment with an increase in the IFN-gamma producing Th1 type cells. Application of such immunotherapy in conjunction with antiparasite drugs may result in faster or more certain cure of the disease in humans. (C) 2000 Elsevier Science Ltd. All rights reserved.
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