期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 152, 期 1, 页码 84-90出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/152.1.84
关键词
arsenic; epidemiologic studies; metals, heavy
资金
- NCI NIH HHS [CA 57494, CA61108] Funding Source: Medline
- NIEHS NIH HHS [ES-07373] Funding Source: Medline
A study was conducted to evaluate toenail arsenic concentrations as a biologic marker of drinking water arsenic exposure. Study subjects were controls in a US population-based case-control study of nonmelanoma skin cancer, randomly selected from drivers' license records (those <65 years of age) and Medicare enrollment files (those greater than or equal to 65 years of age). Between 1994 and 1997, a total of 540 controls were interviewed and toenail samples of sufficient weight were collected from 506 (93.7%) of these. Beginning in 1995, a sample of tap water was taken from the participants' homes; a total of 217 (98.6%) water samples were obtained from the 220 subjects interviewed. Arsenic determinations were made from toenail samples using neutron activation analysis. Water samples were analyzed using hydride-generation magnet sector inductively coupled mass spectrometry. Among 208 subjects with both toenail and water measurements, the correlation (r) between water and nail arsenic was 0.65 (p < 0.001) among those with water arsenic concentrations of 1 mu g/liter or higher and 0.08 (p = 0.31) among those with concentrations below 1 mu g/liter(overall r = 0.46, p < 0.001). Our data suggest that toenail samples provide a useful biologic marker for quantifying low-level arsenic exposure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据