期刊
VACCINE
卷 18, 期 26, 页码 3040-3049出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(00)00079-7
关键词
annual influenza vaccination; HIV-infection; CD4(+) T-lymphocytes
In a consecutive 3-year study the antibody response after immunization with influenza vaccine of a cohort of HIV-infected adults was studied. The haemagglutination-inhibiting (HAI) antibody titres after vaccination correlated with the number of CD4(+) T lymphocytes (p < 0.001), the prevaccination antibody titres (p < 0.001), and the proliferative response to anti-CD3 (p < 0.001). Severely impaired antibody responses were observed in HIV-infected individuals with CD4(+) T-lymphocyte counts less than or equal to 100 x 10(6)/l. Significantly higher prevaccination antibody titres were observed in healthy controls in the 2nd or 3rd year of vaccination, but not in HIV-infected individuals. Annually repeated vaccination of HIV-infected individuals did not lead to higher postvaccination antibody titres. Annual vaccination of HIV-infected individuals with CD4(+) T-lymphocyte counts exceeding 100 x 10(6)/l seems to be worthwhile, although it may not be expected to render the same level of protection against influenza as in non-infected individuals. (C) 2000 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据