期刊
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
卷 44, 期 1, 页码 301-312出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1056-8719(00)00113-1
关键词
permeability; absorption; physicochemical properties; in vitro; in silica; in vivo
This review article will focus on the various techniques that are currently employed by drug discovery scientists in evaluating permeability/absorption of drug candidates during the drug candidate selection process. Various preclinical methodologies are available; each having advantages and disadvantages, but it is the judicious use of these techniques that can help identify drug candidates that will be well absorbed in humans. It is well recognized that the human intestinal permeability cannot be accurately predicted based on a single methodology (in vitro: tissue/cell culture, in situ, or in vivo). (C) 2001 Elsevier Science Inc. All rights reserved.
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