期刊
RESEARCH IN MICROBIOLOGY
卷 151, 期 6, 页码 445-451出版社
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0923-2508(00)00171-6
关键词
Streptococcus pneumoniae; quorum sensing; regulon; genetic transformation; peptide pheromone
类别
Competence for genetic transformation in pneumococcus depends on the coordinated functioning of a dispersed regulon responsible for production of proteins active in DNA binding, uptake, and recombination. This regulon is characterized by a shared noncanonical promoter consensus, TACGAATA, and is capable of 100-fold expression modulations. This review discusses recent evidence that its regulation depends on a novel sigma factor, itself controlled by an autostimulatory quorum sensing system that acts through an extracellular peptide signal. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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