期刊
BIOTECHNOLOGY ADVANCES
卷 18, 期 4, 页码 289-301出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0734-9750(00)00039-2
关键词
penicillins; 6-aminopenicillanic acid; 6-APA; penicillin acylases; immobilization; E. coli
This article elaborates on the important recent developments in the enzymatic transformation of penicillins to 6-aminopenicillanic acid (B-APA), which is the basic raw material for the industrial production of semisynthetic penicillins such as amoxycillin and ampicillin. Particular emphasis is placed on the improvements in purification, stability, and immobilization of the enzymes, (i.e. penicillin acylases) used for these transformations. (C) 2000 Elsevier Science Inc. All rights reserved.
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