期刊
JOURNAL OF VIROLOGY
卷 74, 期 13, 页码 6162-6167出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.13.6162-6167.2000
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- NIAID NIH HHS [AI36071, T32 AI007172, AI34736, AI07172] Funding Source: Medline
Human immunodeficiency virus type 2 (HIV-2), like other lentiviruses, is capable of infecting nondividing T cells and macrophages. The present work shows that in HIV-2-infected cells, Vpx is necessary for efficient nuclear import of the preintegration complex. In agreement with this finding, the subcellular Localization of a GFP-Vpx fusion protein was found to be predominantly nuclear, However, deletion of the proline-rich C-terminal 11 residues of Vpx resulted in a shift of the fusion protein to the cytoplasm, Furthermore, the same deletion in the context of the provirus resulted in a decrease in nuclear import of the preintegration complex and attenuated replication in macrophages.
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