期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 143, 期 3, 页码 1223-1238出版社
HUMANA PRESS INC
DOI: 10.1007/s12011-011-8972-6
关键词
Boron; Calcium fructoborate; Osteoporosis; Osteoarthritis; Anti-inflammatory; Antioxidant
Calcium fructoborate is a boron-based nutritional supplement. Its chemical structure is similar to one of the natural forms of boron such as bis-manitol, bis-sorbitol, bis-fructose, and bis-sucrose borate complexes found in edible plants. In vitro studies revealed that calcium fructoborate is a superoxide ion scavenger and anti-inflammatory agent. It may influence macrophage production of inflammatory mediators, can be beneficial for the suppression of cytokine production, and inhibits progression of endotoxin-associated diseases, as well as the boric acid and other boron sources. The mechanisms by which calcium fructoborate exerts its beneficial anti-inflammatory effects are not entirely clear, but some of its molecular biological in vitro activities are understood: inhibition of the superoxide within the cell; inhibition of the interleukin-1 beta, interleukin-6, and nitric oxide release in the culture media; and increase of the tumor necrosis factor-alpha production. Also, calcium fructoborate has no effects on lipopolysaccharide-induced cyclooxygenase-2 protein express. The studies on animals and humans with a dose range of 1-7 mg calcium fructoborate (0.025-0.175 mg elemental boron)/kg body weight/day exhibited a good anti-inflammatory activity, and it also seemed to have negligible adverse effect on humans.
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