期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 141, 期 1-3, 页码 254-261出版社
HUMANA PRESS INC
DOI: 10.1007/s12011-010-8726-x
关键词
Influenza virus; Selenium; Mortality; Viral titer; TNF-alpha; IFN-gamma
资金
- HeiLongJiang Provincial Health Department [2009-201]
The present paper describes protective effects of supplemental selenium in mice infected with influenza virus. The effects of supplemental selenium on serum selenium levels, mortality, lung virus titers, and cytokine titers were investigated in mice inoculated intranasally with suspensions of influenza virus. Whereas the mortality of the virus-infected Se-deficient mice was 75%, along with a marked reduction in body weight, lower levels of TNF-alpha and IFN-gamma and lower serum selenium concentrations, the mortality of mice maintained on feed containing 0.5 mg Se/kg in the form of sodium selenite was 25%.There were no significantly differences, however, in viral titer between the Se-adequate and the selenium-supplemented groups. The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.
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